LKT Labs

Biochemicals for Life Science Research

Furosemide

Furosemide

Product ID F8270
Cas No. 54-31-9
Purity ≥97%
Product Unit SizeCostQuantityStock
10 g $107.20 In stock
25 g $203.70 In stock
5 g $63.70 In stock
Bulk Quote

Quicklinks

Description

Furosemide is a loop diuretic that is clinically used to treat congestive heart failure, edema, and hypertension; it inhibits the Na+/K+/Cl2- (NKCC) symporter and CFTR Cl- channels in the loop of Henle, decreasing reabsorption of Na+ and K+ and increasing secretion of Mg2+ and Ca2+. Furosemide exhibits antihypertensive, anxiolytic, and potentially antiepileptic/anticonvulsant activities. Furosemide noncompetitively inhibits GABA-A receptors and decreases conditioned anxiety in animal models of contextual fear conditioning and fear-potentiated startle.

Product Info

Cas No.

54-31-9
Purity

≥97%
Formula

C12H11ClN2O5S
Formula Wt.

330.74
Chemical Name

5-(Aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)- amino]benzoic acid
IUPAC Name

4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid
Synonym

Fursemide, Beronald, Discoid, Durafurid, Eutensin, Fulsix, Furosedon, Impugan, Katlex, Lasix, Macasirrol, Nicorol, Odemase, Rosemide, Urex
Melting Point

203-206°C

Solubility

Soluble in acetone, DMF, and methanol. Slightly soluble in water, chloroform and ether.

Appearance

Cream/ Off-White powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

F8270 MSDS PDF
Info Sheet

F8270 Info Sheet PDF

References

Ju M, Scott-Ward TS, Liu J, et al. Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics. Br J Pharmacol. 2014 Jan;171(1):265-78. PMID: 24117047.

Krystal AD, Sutherland J, Hochman DW. Loop diuretics have anxiolytic effects in rat models of conditioned anxiety. PLoS One. 2012;7(4):e35417. PMID: 22514741.

Somasekharan S, Tanis J, Forbush B. Loop diuretic and ion-binding residues revealed by scanning mutagenesis of transmembrane helix 3 (TM3) of Na-K-Cl cotransporter (NKCC1). J Biol Chem. 2012 May 18;287(21):17308-17. PMID: 22437837.

Korpi ER, Kuner T, Seeburg PH, et al. Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol Pharmacol. 1995 Feb;47(2):283-9. PMID: 7870036.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G0668

    GBR 12935 Dihydrochloride

    DAT inhibitor.
    ≥98%
  • U6860

    Urocortin III, mouse

    Endogenous peptide, involved in stress signaling; ...
    ≥95%
  • K0034

    Kahweol Eicosanate

    Diterpene found in coffee beans.
    ≥98%
  • V5870

    Vortioxetine

    5-HT1A agonist, 5-HT1B partial agonist, 5-HT3A/7 a...
    ≥98%
  • A6017

    Apelin-13, human/cow

    Endogenous peptide, involved in vascular contracti...
    ≥95%
  • A0962

    Adrenocorticotropic Hormone (1-4)

    Endogenous peptide hormone fragment, involved in s...
    ≥95%
  • I7478

    Istradefylline

    Adenosine A2A antagonist.
    ≥98%
  • O7116

    Orexin B, human

    Endogenous peptide neurotransmitter, involved in c...
    ≥95%
  • J6400

    (+)-JQ-1

    Triazolothienodiazepine; BRD inhibitor.
    ≥99%
  • O9396

    Oxytetracycline

    Tetracycline; protein translation inhibitor.
    ≥96%
  • R1752

    Renin Inhibitor Peptide

    Peptide; potential vasodilator.
    ≥95%
  • A2400

    AG-1024

    Tyrphostin; IGF-1R inhibitor.
    ≥98%
  • A1334

    AdipoRon

    Adiponectin agonist.
    ≥98%
  • A7658

    Atorvastatin Calcium Trihydrate

    Statin; HMG-CoA reductase inhibitor.
    ≥98%
  • T7232

    S-Trityl-L-cysteine

    Organosulfur found in garlic; kinesin Eg5 inhibito...
    ≥98%
  • L3561

    D,L-α-Lipoic Acid

    Endogenous organosulfur also found in meat and veg...
    ≥98%
  • V1870

    Verruculogen

    Mycotoxin produced by Aspergillus; BK K+ channel b...
    ≥95%
  • G0244

    alpha-Galactosylceramide

    Synthetic glycolipid found in Agelas mauritanius; ...
    ≥96%
  • C7097

    Cryptotanshinone

    Quinoid diterpene found in species of Salvia; STAT...
    ≥90%
  • R1877

    all-trans-Retinol, ≥98 %

    Diterpene vitamin A; RAR/RXR agonist.
    ≥98%