LKT Labs

Biochemicals for Life Science Research

Fumagillin

Fumagillin

Product ID F8048
Cas No. 23110-15-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $62.40 In stock
5 mg $208.10 In stock
Bulk Quote

Quicklinks

Description

Fumagillin is an antimicrobial compound initially produced by species of Aspergillus that exhibits anti-parasitic, antimalarial, anti-fibrotic, anti-angiogenic, and anticancer chemotherapeutic activities. Fumagillin is clinically used to treat microsporidiosis and displays efficacy against Plasmodium, Nosema, and Enterocytozoon. In vivo, fumagillin decreases pulmonary fibrosis, pulmonary hypertension, and ventricular remodeling. In cellular and animal models of colorectal cancer, fumagillin inhibits type 2 methionine aminopeptidase, preventing tube and vessel formation and well as cell proliferation, migration, and adhesion; it also decreases tumor mass.

Product Info

Cas No.

23110-15-8
Purity

≥98%
Formula

C26H34O7
Formula Wt.

458.54
Chemical Name

[3R-[3α,4α(2R*,3R*),5β,6β(all-E)]]-2,4,6,8-Decatetra- enedioic acid, mono[5-methoxy-4-[2-methyl-3-(3- methyl- 2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] ester
IUPAC Name

(2Z,4E,6E, 8E)-10-[[5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1- oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
Synonym

Amebacilin, Fugillin, Fumadil B: Fumidil

Melting Point

194-195°C
Solubility

Soluble in most organic solvents. Practically insoluble in water, dilute acids and saturated hydrocarbons.

Appearance

Off white Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

F8048 MSDS PDF
Info Sheet

F8048 Info Sheet PDF

References

Kass DJ, Rattigan E, Kahloon R, et al. Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats. PLoS One. 2012;7(4):e35388. PMID: 22509410.

Champion L, Durrbach A, Lang P, et al. Fumagillin for treatment of intestinal microsporidiosis in renal transplant recipients. Am J Transplant. 2010 Aug;10(8):1925-30. PMID: 20636462.

Arico-Muendel C, Centrella PA, Contonio BD, et al. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5128-31. PMID: 19648008.

Hou L, Mori D, Takase Y, et al. Fumagillin inhibits colorectal cancer growth and metastasis in mice: in vivo and in vitro study of anti-angiogenesis. Pathol Int. 2009 Jul;59(7):448-61. PMID: 19563408.

Chen X, Xie S, Bhat S, et al. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol. 2009 Feb 27;16(2):193-202. PMID: 19246010.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T5946

    Toltrazuril

    Coccidiostat; mitochondrial respiration inhibitor,...
    ≥98%
  • S8098

    SU-1498

    Tyrphostin; VEGFR inhibitor.
    ≥98%
  • T0108

    10-Deacetyl-7-xylosyltaxol

    Taxane found in species of Taxus; potential microt...
    ≥98%
  • Z4552

    ZLN005

    PPARγ coactivator-1α expression stimulator.
    ≥98%
  • M1778

    S-(+)-α−Methylbenzyl Isothiocyanate

    ITC, used as chiral agent.
    ≥98%
  • G4484

    Glucagon-like Peptide II, rat

    Endogenous peptide hormone, involved in intestinal...
    ≥95%
  • M0248

    Manidipine Dihydrochloride

    Dihydropyridine; L-type and T-type Ca2+ channel bl...
    ≥98%
  • B1640

    Benzydamine Hydrochloride

    NSAID; PG synthetase inhibitor.
    ≥98%
  • B6816

    Brefeldin A

    Lactone found in fungi such as Eupenicillium; guan...
    ≥97%
  • W0272

    S-(−)-Warfarin >99

    Coumarin, more potent isomer; VKORC1 inhibitor.
    ≥98%
  • A7034

    Aripiprazole

    D2 and 5-HT1A partial agonist, 5-HT2C/6/7 antagoni...
    ≥98%
  • L1980

    Leucokinin I

    Peptide found in insects.
    ≥95%
  • L1780

    Levocetirizine Dihydrochloride

    L-isomer of cetirizine; histamine H1 antagonist.
    ≥98%
  • E6896

    Erysolin

    ITC found in cruciferous vegetables, analog of sul...
    ≥97%
  • G3254

    10-Gingerol

    Phenol found in Zingiber; 5-HT3 antagonist.
    ≥99%
  • A7868

    Atropine

    Tropane alkaloid found in plants in the Solanaceae...
    ≥98%
  • C0366

    Carvedilol Phosphate Hemihydrate

    FIASMA; α1- and β1/2-adrenergic antagonist.
    ≥98%
  • S6134

    Spinorphin, cow

    Endogenous heptapeptide; P2X3 and N-formylpeptide ...
    ≥95%
  • H1658

    Heparin Sodium

    Endogenous glycosaminoglycan that is produced by m...
    ≥98%
  • D5610

    Docosahexaenoic Acid (all cis-4,7,10,13,16,19)

    Essential fatty acid found in fish oil, involved i...
    ≥99%