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Formoterol is a long-acting β2-adrenergic receptor agonist that is clinically used to treat asthma and chronic obstructive pulmonary disease (COPD). Formoterol exhibits bronchodilatory, anti-asthma, and anti-obesity activities. In a clinical setting, formoterol increases resting energy expenditure, fat utilization, and mitochondrial biogenesis; it also increases mitochondrial expression of NADH dehydrogenase and ATP synthase. TEST!!!!!!
| Cas No. | 183814-30-4 |
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| Purity | ≥98% |
| Formula | (C19H24N2O4)2 • C4H4O4 • 2H2O |
| Formula Wt. | 840.91 |
| Chemical Name | rel-N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4- methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]- formamide fumarate dihydrate |
| IUPAC Name | (E)-but-2-enedioic acid;N-[2-hydroxy-5-[(1S)-1-hydroxy-2-[[(2S)-1-(4-methoxyphenyl)propan- 2-yl]amino]ethyl]phenyl]formamide |
| Synonym | Formoterol Fumarate Dihydrate, Atock, Foradil, Oxeze |
| Melting Point | 138-140°C |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Lee P, Day RO, Greenfield JR, et al. Formoterol, a highly β2-selective agonist, increases energy expenditure and fat utilisation in men. Int J Obes (Lond). 2013 Apr;37(4):593-7. PMID: 22641064.
Wills LP, Trager RE, Beeson GC, et al. The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis. J Pharmacol Exp Ther. 2012 Jul;342(1):106-18. PMID: 22490378.
Rider CF, King EM, Holden NS, et al. Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. J Pharmacol Exp Ther. 2011 Sep;338(3):860-9. PMID: 21622733.