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Fibrinogen γ-chain dodecapeptide binds glycoprotein GP IIb/IIIa on platelets, exhibiting hemostatic, pro-thrombotic activity and enhancing thrombus formation. This peptide rescues thrombocytopenic rabbits from liver hemorrhage and is clinically used as a platelet substitute.
| Cas No. | 89105-94-2 |
|---|---|
| Purity | ≥98% |
| Formula | C50H80N18O16 |
| Formula Wt. | 1189.29 |
| Synonym | Fibrinogen gamma-chain dodecapeptide, Fibrinogen Binding Inhibitor Peptide |
| Solubility | Soluble in water (2 mg/mL). |
| Appearance | White powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Tokutomi K, Tagawa T, Korenaga M, et al. Ability of fibrinogen γ-derived dodecapeptides with different sequences to bind to rat platelets. Int J Pharm. 2012 Nov 15;438(1-2):296-301. PMID: 22985603.
Nishikawa K, Hagisawa K, Kinoshita M, et al. Fibrinogen γ-chain peptide-coated, ADP-encapsulated liposomes rescue thrombocytopenic rabbits from non-compressible liver hemorrhage. J Thromb Haemost. 2012 Oct;10(10):2137-48. PMID: 22905905.
Okamura Y, Maekawa I, Teramura Y, et al. Hemostatic effects of phospholipid vesicles carrying fibrinogen gamma chain dodecapeptide in vitro and in vivo. Bioconjug Chem. 2005 Nov-Dec;16(6):1589-96. PMID: 16287259.