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Erythromycin is a macrolide antibiotic that binds the 50s subunit of bacterial ribosomes, inhibiting protein synthesis by preventing transfer of tRNA from the A site to the P site. This compound displays antibacterial activity against both gram positive and gram negative bacteria; it also inhibits mammalian mRNA splicing.
| Cas No. | 114-07-8 |
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| Purity | ≥94% |
| Formula | C37H67NO13 |
| Formula Wt. | 733.93 |
| Chemical Name | Erythromycin A |
| IUPAC Name | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S, 6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12, 13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4, 6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2, 10-dione |
| Synonym | Abomacetin, Aknin, EMU, E-Mycin, Erymax, Erycen, Erycin. |
| Melting Point | 135-140°C |
| Solubility | Very slightly soluble in water (~2 mg/ml). Freely soluble in alcohols, acetone, ethyl acetate, acetonitrile or chloroform. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Hertweck M, Hiller R, Mueller MW. Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro. Eur J Biochem. 2002 Jan;269(1):175-83. PMID: 11784311.
Menninger JR, Otto DP. Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. Antimicrob Agents Chemother. 1982 May;21(5):811-8. PMID: 6179465.