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Endothelin-1 is an endogenous peptide agonist at endothelin A and B (ET-A/B) receptors that exhibits anti-angiogenic and vasoconstrictive activities. Endothelin-1 decreases tube formation and PPARγ expression in pulmonary artery endothelial cells. This peptide also increases expression of IL-18 in osteoblasts, inducing proliferation.
| Cas No. | 117399-94-7 |
|---|---|
| Purity | ≥95% |
| Formula | C109H159N25O32S5 |
| Formula Wt. | 2491.95 |
| Synonym | ET-1. |
| Solubility | Soluble in 1% acetic acid (1 mg/mL), water (1 mg/mL), 50% acetonitrile (1 mg/mL). |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zhong X, Wang H, Huang S. Endothelin-1 induces interleukin-18 expression in human osteoblasts. Arch Oral Biol. 2014 Mar;59(3):289-96. PMID: 24581851.
Osmond JM, Gonzalez Bosc LV, Walker BR, et al. Endothelin-1-induced vasoconstriction does not require intracellular Ca2+ waves in arteries from rats exposed to intermittent hypoxia. Am J Physiol Heart Circ Physiol. 2014 Mar;306(5):H667-73. PMID: 24414066.
Wolf D, Tseng N, Seedorf G, et al. Endothelin-1 decreases endothelial PPARγ signaling and impairs angiogenesis after chronic intrauterine pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(4):L361-71. PMID: 24337925.