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Desloratadine is a non-sedating tricyclic antihistamine that inhibits H1 histamine receptors. Desloratidine is an active metabolite of loratadine that exhibits anti-allergic, anti-asthma, and anti-inflammatory activities. Desloratadine inhibits histamine-induced bronchoconstriction and is clinically used to treat allergic rhinitis and chronic idiopathic urticaria. This compound also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).
| Cas No. | 100643-71-8 |
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| Purity | ≥97% |
| Formula | C19H19ClN2 |
| Formula Wt. | 310.82 |
| Chemical Name | 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine |
| IUPAC Name | 8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2, 4-b]pyridine |
| Synonym | Clarinex |
| Melting Point | 150-151°C |
| Solubility | Soluble in methanol and ethanol. |
| Appearance | White to off white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Doetkotte R, Opitz K, Kiianmaa K, et al. Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol. 2005 Oct 17;522(1-3):72-7. PMID: 16209867.
Glass DJ, Harper AS. Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine. BMC Fam Pract. 2003 Aug 13;4:10. PMID: 12917016.
Walsh GM. Second-generation antihistamines in asthma therapy: is there a protective effect? Am J Respir Med. 2002;1(1):27-34. PMID: 14720073.