LKT Labs

Biochemicals for Life Science Research

Awaiting product image

Clofibric Acid

Product ID C4556
Cas No. 882-09-7
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $38.30 In stock
50 g $60.70 In stock
Bulk Quote

Quicklinks

Description

Clofibric acid is a metabolite of clofibrate that activates PPARα receptors and inhibits auxin activity, exhibiting anti-hyperlipidemic, anti-angiogenic, anticancer chemotherapeutic, and herbicidal activity. Clofibric acid alters plant hormone activity and is used as a plant growth regulator. Clofibric acid also inhibits phosphatidylethanolamine synthesis, decreasing production of cholesterol and activity of HMG-CoA reductase and ACAT. Additionally, clofibric acid suppresses production of prostaglandin E2 (PGE2) and VEGF, decreases vessel density, and inhibits tumor growth in animal models of ovarian cancer. TEST!!!!!!

Product Info

Cas No.

882-09-7
Purity

≥98%
Formula

C10H11ClO3
Formula Wt.

214.65
Chemical Name

2-(4-Chlorophenoxy)-2-methylpropanoic acid
IUPAC Name

2-(4-chlorophenoxy)-2-methylpropanoic acid
Synonym

Chlorfibrinic acid, Arteriohom, Regulipid
Melting Point

118-119°C

Appearance

Light Yellow Fine Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C4556 MSDS PDF
Info Sheet

C4556 Info Sheet PDF

References

Yokoyama Y, Xin B, Shigeto T, et al. Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer. Mol Cancer Ther. 2007 Apr;6(4):1379-86. PMID: 17431116.

Nishimaki-Mogami T, Suzuki K, Okochi E, et al. Bezafibrate and clofibric acid are novel inhibitors of phosphatidylcholine synthesis via the methylation of phosphatidylethanolamine. Biochim Biophys Acta. 1996 Nov 11;1304(1):11-20. PMID: 8944746.

Haughom B, Spydevold O. The mechanism underlying the hypolipemic effect of perfluorooctanoic acid (PFOA), perfluorooctane sulphonic acid (PFOSA) and clofibric acid. Biochim Biophys Acta. 1992 Sep 22;1128(1):65-72. PMID: 1327145.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A001001

    A 83-01

    ≥98%
  • L5749

    Lomefloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • E7329

    Ethoxyquin

    Quinoline, food preservative; HSP90 inhibitor.<...

    ≥90%
  • C0351

    Carprofen

    NSAID; COX-2 inhibitor.

    ≥98%
  • C0253

    Candesartan

    AT1 inhibitor.

    ≥98%
  • E7376

    Estradiol

    Endogenous steroid hormone, involved in regulat...

    ≥97%
  • R3222

    Rifamycin SV Monosodium

    Ansamycin; bacterial DNA-dependent RNA polymera...

    ≥98%
  • M5853

    Moniliformin

    Mycotoxin produced by species of Fusarium; pote...

    ≥98%
  • O4102

    Okadaic Acid Ammonium

    Shellfish toxin produced by dinoflagellates and...

    ≥98%
  • M9368

    Myristicin

    Allylbenzene found in spices and umbelliferous ...

    ≥97%
  • S8044

    R,S-Sulforaphane, High Purity

    Phase II enzyme inducer; Nrf2 activator; antiox...

    ≥99%
  • P327211

    Pifithrin-α Hydrobromide

    p53 inhibitor

    ≥98%
  • L9800

    LY-364947

    ALK5 (activin-like) inhibitor.

    ≥98%
  • T9970

    Tyrphostin AG1295

    PDGFR inhibitor.

    ≥98%
  • T8004

    Tubeimoside I

    Triterpene saponin originally found in Bolboste...

    ≥96%
  • B349921

    BIX-01294

    Specific inhibitor of histone methyltransferase...

    ≥99%
  • O0830

    Ochratoxin B

    ≥99%
  • C2968

    Chrysin

    Flavone found in Passiflora, Oroxylum, and Pleu...

    ≥98%
  • A0960

    Adrenocorticotropic Hormone (1-39), human

    Endogenous peptide hormone, involved in stress ...

    ≥95%
  • C864760

    CVT-313

    Selective CDK2 inhibitor.

    ≥98%