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Cisatracurium is a non-depolarizing neuromuscular junction (NMJ) blocker; it binds the α-δ interface of postsynaptic nicotinic acetylcholine receptors (nAChRs). Cisatracurium acts as a skeletal muscle relaxant and is an isomer of parent compound atracurium. Cisatracurium also suppresses atrial fibrillation and prevents action potential shortening in vivo, indicating additional inhibition of M2 muscarinic acetylcholine receptors (mAChRs) in the atrium.
| Cas No. | 96946-42-8 |
|---|---|
| Purity | ≥98% |
| Formula | C53H72N2O12 • 2C6H5O3S |
| Formula Wt. | 1243.48 |
| IUPAC Name | benzenesulfonate;5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6, 7-dimethoxy-2-methyl-3, 4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[(1S,2S)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3, 4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate |
| Appearance | Slightly yellow powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Liu M, Dilger JP. Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33. PMID: 18633030.
Patterson E, Scherlag BJ, Zhou J, et al. Antifibrillatory actions of cisatracurium: an atrial specific M2 receptor antagonist. J Cardiovasc Electrophysiol. 2008 Aug;19(8):861-8. PMID: 18363689.
Dilger JP, Vidal AM, Liu M, et al. Roles of amino acids and subunits in determining the inhibition of nicotinic acetylcholine receptors by competitive antagonists. Anesthesiology. 2007 Jun;106(6):1186-95. PMID: 17525594.
Jonsson M, Gurley D, Dabrowski M, et al. Distinct pharmacologic properties of neuromuscular blocking agents on human neuronal nicotinic acetylcholine receptors: a possible explanation for the train-of-four fade. Anesthesiology. 2006 Sep;105(3):521-33. PMID: 16931985.