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Cheirolin is an isothiocyanate (ITC) that exhibits antioxidative activity. Cheirolin is a sulfonyl analog of iberin. Like others ITCs, cheirolin induces phase II enzymes. In vitro, cheirolin increases activation and expression of Nrf2 as well as expression of heme oxygenase 1 (HO-1) and γ-glutamylcysteine synthetase.
| Cas No. | 505-34-0 |
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| Purity | ≥97% |
| Formula | C5H9NO2S2 |
| Formula Wt. | 179.26 |
| Chemical Name | 1-Isothiocyanato-3-(methylsulfonyl)-propane |
| IUPAC Name | 1-isothiocyanato-3-methylsulfonylpropane |
| Synonym | 3-(Methylsulfonyl)-propyl isothiocyanate |
| Melting Point | 47.5°C |
| Solubility | Slightly soluble in water, ether; freely soluble in alcohol, chloroform, ethyl acetate. |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ernst IM, Palani K, Esatbeyoglu T, et al. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Pharmacol Res. 2013 Apr;70(1):155-62. PMID: 23403058.