Description
Calyculin A is an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A) that was first found in Discodermia. TEST!!!!!!
Calyculin A
Product ID C0346
Cas No. 101932-71-2
Purity ≥98%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 101932-71-2 |
|---|---|
| Purity | ≥98% |
| Formula | C50H81N4O15P |
| Formula Wt. | 1009.17 |
| Chemical Name | N-[(3S)-3-[4-[(1E)-3-[(2R,3R,5R,7S,8S,9R)-2-[(1S,3S,- 4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1- methyoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradeca- tetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphono- oxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxa- zolyl]-butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide |
| IUPAC Name | [(2R,3R,5R,7R,8S,9S)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3, 5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyltetradeca-7,9,11, 13-tetraenyl]-9-[(E)-3-[2-[(2S)-4-[[(2S,3S,4S)-4-(dimethylamino)-2, 3-dihydroxy-5-methoxypentanoyl]amino]butan-2-yl]-1, 3-oxazol-4-yl]prop-2-enyl]-7-hydroxy-4,4,8-trimethyl-1, 10-dioxaspiro[4.5]decan-3-yl] dihydrogen phosphate |
| Synonym | (-)-Calyculin A |
| Melting Point | 247-249°C |
| Solubility | Soluble in DMSO or ethanol. |
| Appearance | Clear film |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Iida Y, Yamamori S, Itakura M, et al. Protein phosphatase 2A dephosphorylates SNAP-25 through two distinct mechanisms in mouse brain synaptosomes. Neurosci Res. 2013 Mar;75(3):184-9. PMID: 23376809.
Palfrey HC, Pewitt EB. The ATP and Mg2+ dependence of Na(+)-K(+)-2Cl- cotransport reflects a requirement for protein phosphorylation: studies using calyculin A. Pflugers Arch. 1993 Nov;425(3-4):321-8. PMID: 8309793.