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Butoconazole is an imidazole derivative that exhibits antifungal/antimycotic and anti-parasitic activities; it likely inhibits 14-α demethylase. Butoconazole displays particularly effective antimicrobial activity against species of Candida, Saccharomyces, and Trichomonas.
| Cas No. | 64872-77-1 |
|---|---|
| Purity | ≥98% |
| Formula | C19H17Cl3N2S • HNO3 |
| Formula Wt. | 474.79 |
| IUPAC Name | 1-[4-(4-chlorophenyl)-2-(2, 6-dichlorophenyl)sulfanylbutyl]imidazole;nitric acid |
| Melting Point | 159°C (dec.) |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Seidman LS, Skokos CK. An evaluation of butoconazole nitrate 2% site release vaginal cream (Gynazole-1) compared to fluconazole 150 mg tablets (Diflucan) in the time to relief of symptoms in patients with vulvovaginal candidiasis. Infect Dis Obstet Gynecol. 2005 Dec;13(4):197-206. PMID: 16338779.
Bourée P, Issoire C. In vitro evaluation of the activity of butoconazole against Trichomonas vaginalis. Pathol Biol (Paris). 1992 May;40(5):492-4. PMID: 1495832.
Hernández Molina JM, Llosá J, Martinez Brocal A, et al. In vitro activity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates of Candida albicans and Candida spp. Mycopathologia. 1992 Apr;118(1):15-21. PMID: 1406898.