LKT Labs

Biochemicals for Life Science Research

Bupropion Hydrochloride

Bupropion Hydrochloride

Product ID B8363
Cas No. 31677-93-7
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $97.30 In stock
250 mg $262.20 In stock
1 g $674.20 In stock
Bulk Quote

Quicklinks

Description

Bupropion is an antidepressant that is also commonly used as a smoking cessation aid. This compound has additional therapeutic potential, as it promotes modest weight loss, shows efficacy as an ADHD treatment, and may also be an effective treatment for neuropathic pain. Bupropion is a DA and NE reuptake inhibitor, decreasing the firing rate of NE neurons due to activation of their inhibitory somatodendritic α2-adrenoreceptors by circulating NE; bupropion’s effects on NE reuptake are somewhat stronger than its effects on DA reuptake. Additionally, bupropion is a noncompetitive antagonist at α3β2, α3β4, α4β2 nicotinic acetylcholine receptors (nAChRs), decreasing the probability of channel opening in closed nAChRs and accelerating desensitization in open nAChRs.

Product Info

Cas No.

31677-93-7
Purity

≥98%
Formula

C13H18ClNO • HCl
Formula Wt.

276.2
IUPAC Name

2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydrochloride
Synonym

Wellbutrin
Melting Point

236.0-238.0
Solubility

50 mg/ml MeOH
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

B8363 MSDS PDF
Info Sheet

B8363 Info Sheet PDF

References

Shah TH, Moradimehr A. Bupropion for the treatment of neuropathic pain. Am J Hosp Palliat Care. 2010 Aug;27(5):333-6. PMID: 20185402.

Arias HR. Is the inhibition of nicotinic acetylcholine receptors by bupropion involved in its clinical actions? Int J Biochem Cell Biol. 2009 Nov;41(11):2098-108. PMID: 19497387.

Li Z, Maglione M, Tu W, et al. Meta-analysis: pharmacologic treatment of obesity. Ann Intern Med. 2005 Apr 5;142(7):532-46. PMID: 15809465.

Miller DK, Sumithran SP, Dwoskin LP. Bupropion inhibits nicotine-evoked [(3)H]overflow from rat striatal slices preloaded with [(3)H]dopamine and from rat hippocampal slices preloaded with [(3)H]norepinephrine. J Pharmacol Exp Ther. 2002 Sep;302(3):1113-22. PMID: 12183670.

Dong J, Blier P. Modification of norepinephrine and serotonin, but not dopamine, neuron firing by sustained bupropion treatment. Psychopharmacology (Berl). 2001 Apr;155(1):52-7. PMID: 11374336.

Cantwell DP. ADHD through the life span: the role of bupropion in treatment. J Clin Psychiatry. 1998;59 Suppl 4:92-4. PMID: 9554326.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A7202

    AS-604850

    p110γ PI3K inhibitor.
    ≥98%
  • K1678

    Ketanserin

    5-HT2A antagonist, potential α1-adrenergic antago...
    ≥97%
  • P2919

    L-Phenylalaninol

    Non-essential amino acid alcohol.
    ≥98%
  • M0035

    M35

    Peptide; galanin antagonist.
    ≥95%
  • G2873

    Growth Hormone Releasing Factor, sheep

    Endogenous peptide hormone, involved in growth hor...
    ≥95%
  • L9600

    LY-2090314

    GSK-3 inhibitor.
    ≥98%
  • A9834

    Azithromycin Dihydrate

    Azalide macrolide; protein translation inhibitor.
    ≥98%
  • F1854

    Fenticonazole Nitrate

    Imidazole; 14-α demethylase inhibitor, potential ...
    ≥98%
  • H0207

    Hepatitis B Virus Core Protein (128-140)

    B cell epitope found on hepatitis B viral core pro...
    ≥95%
  • N4972

    NMS-873

    Valosin-containing protein inhibitor.
    ≥98%
  • C0262

    L-Carnitine

    Endogenous quaternary ammonium, required for fatty...
    ≥98%
  • V3476

    Vitamin D2

    Vitamin D prodrug produced by fungi and alfalfa.
    ≥91%
  • A5061

    Ampalex

    Benzylpiperidine; AMPA potentiator.
    ≥98%
  • E5210

    Endomorphin-1

    Endogenous opioid peptide; μOr agonist.
    ≥95%
  • S0132

    Saikosaponin A

    Triterpene saponin found in Bupleurum.
    ≥98%
  • F4680

    Flutamide

    Non-steroid; AR antagonist.
    ≥98%
  • O7218

    Oseltamivir Phosphate

    Viral neuraminidase inhibitor, potential MAO-A inh...
    ≥98%
  • F4881

    Flumequine Sodium

    Fluoroquinolone; bacterial DNA gyrase inhibitor, G...
    ≥98%
  • N4524

    NLG919

    Indoleamine-2,3-dioxygenase inhibitor.
    ≥98%
  • P6855

    (±)-S-Propyl-L-cysteine-S-oxide

    Organosulfur found in Allium; analog of alliin.
    ≥98%