Description
BIX-01294 is a specific inhibitor of histone methyltransferase G9a. When used to treat pulmonary artery smooth muscle cells, BIX-01294 reduces cell proliferation, migration, and contractility, inducing cell cycle arrest in G(1) phase. A study of cloned mouse preimplantation embryos found that treatment with BIX-01294 corrected abnormal epigenetic modifications. Studies with human glioma stem-like cells demonstrated that BIX-01294 treatment results in sensitization of the cells to treatment with temozolomide, which then induces apoptosis. BIX-01294 has also been found to be a potent modulator of stem cell differentiation. TEST!!!!!!