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Bis(3,5-dibromosalicyl) fumarate is an aspirin analog that is used to induce hemoglobin chain crosslinks at lysine residues. This compound is used to study hemoglobin function in research models and may be used to develop treatments for sickle-cell anemia. This compound may exhibit anti-inflammatory, analgesic, and antipyretic activities.
| Cas No. | 71337-53-6 |
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| Purity | ≥91% |
| Formula | C18H8O8Br4 |
| Formula Wt. | 671.87 |
| Chemical Name | 2-Butenedioic acid (E)-, bis(2,4-dibromo-6-carboxyphenyl) ester |
| IUPAC Name | 3,5-dibromo-2-[(E)-4-(2, 4-dibromo-6-carboxyphenoxy)-4-oxobut-2-enoyl]oxybenzoic acid |
| Synonym | 3,5-Dibromosalicyl-bis-fumarate |
| Melting Point | 225-228°C |
| Solubility | Slightly soluble in water. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376.
Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420.
Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320.