Biapenem

Name: Biapenem
SKU: B3203
Availability: InStock

Product ID B3203

Cas No. 120410-24-4

Purity ≥98%

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Description

Biapenem is a carbapenem β-lactam antibiotic. Like other carbapenems, biapenem binds penicillin-binding proteins to inhibit bacterial cell wall synthesis. Biapenem exhibits broad spectrum antibacterial activity and is clinically used to treat respiratory and urinary tract infections. Biapenem displays activity against several species of bacteria, including Bacteriodes, Prevotella, Clostridium, and Pseudomonas. In animal models of pneumonia, biapenem decreases bacteria numbers and increases survival rates. TEST!!!!!!

Product Info

Cas No.	120410-24-4
Purity	≥98%
Formula	C₁₅H₁₈N₄O₄S
Formula Wt.	350.39
Chemical Name	(4R,5R,6S)-3-(3,5-diaza-1-azoniabicyclo[3.3.0]octa-1,3-dien-7-ylsulfanyl)-6 -(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
IUPAC Name	(4R,5S,6S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2, 4]triazol-4-ium-6-ylsulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1- azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Synonym	6-(((4R,5S,6S)-2-Carboxy-6-((1R)-1-hydroxyethyl)-4-methyl-7- oxo-1-azabicyclo(3.2.0)hept-2-en-3-yl)thio)-6,7-dihydro-5H- pyrazolo(1,2-a)-s-triazol-4-ium hydroxide, inner salt, L-627, CL-186,815, LJ-C10,627
Appearance	Slightly yellow powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	B3203 MSDS PDF
Info Sheet	B3203 Info Sheet PDF

References

Wang X, Zhang X, Zong Z, et al. Biapenem versus meropenem in the treatment of bacterial infections: a multicenter, randomized, controlled clinical trial. Indian J Med Res. 2013 Dec;138(6):995-1002. PMID: 24521647.

Yamachika S, Sugihara C, Kamai Y, et al. Correlation between penicillin-binding protein 2 mutations and carbapenem resistance in Escherichia coli. J Med Microbiol. 2013 Mar;62(Pt 3):429-36. PMID: 23222859.

Yamada K, Yamamoto Y, Yanagihara K, et al. In vivo efficacy and pharmacokinetics of biapenem in a murine model of ventilator-associated pneumonia with Pseudomonas aeruginosa. J Infect Chemother. 2012 Aug;18(4):472-8. PMID: 22215228.

Aldridge KE, Morice N, Schiro DD. In vitro activity of biapenem (L-627), a new carbapenem, against anaerobes. Antimicrob Agents Chemother. 1994 Apr;38(4):889-93. PMID: 8031067.

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Biapenem

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