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AZD-5438 is a Cdk inhibitor that has been found to be a potent radiosensitizer in non-small cell lung cancer. AZD-5438 has also been shown to inhibit human tumor xenograft growth and reduce the proportion of actively cycling cells. TEST!!!!!!
| Cas No. | 602306-29-6 |
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| Purity | ≥98% |
| Formula | C18H21N5O2S |
| Formula Wt. | 371.45 |
| Chemical Name | 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine |
| IUPAC Name | 4-(1-Isopropyl-2-methyl-1H-imidazol-5-yl)-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine |
| Synonym | AZD5438; MMV676604 |
| Solubility | Insoluble in water. Soluble in DMSO (>20 mg/mL). |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Raghavan P, Tumati V, Yu L, et al. AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-514. PMID: 22795803.
Byth KF, Thomas A, Hughes G, et al. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol Cancer Ther. 2009 Jul;8(7):1856-1866. PMID: 19509270.