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Apoptosis activator 2 displays neuromodulatory and anticancer activities, induces apoptosis and cell death in gastric adenocarcinoma cells and neurons. This compound is used to study apoptosis in cancer research and neurodegenerative diseases.
| Cas No. | 79183-19-0 |
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| Purity | ≥98% |
| Formula | C15H9Cl2NO2 |
| Formula Wt. | 306.14 |
| IUPAC Name | 1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione |
| Synonym | AA-2, Apoptosis activator II, AA-II, AAII, N-(3,4-dichlorobenzyl) Isatin, MDK83190 |
| Solubility | DMSO 61 mg/mL (199.25 mM) Water Insoluble Ethanol Insoluble |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Kim JH, Lee J. Induced neural stem cells protect neuronal cells against apoptosis. Med Sci Monit. 2014 Dec 22;20:2759-66. PMID: 25554259.
Farivar TN, Najafipour R, Johari P. Nano - drug Delivery of Apoptosis Activator 2 to AGS Cells by Liposomes Conjugated with Anti-TROP2 Antibody. N Am J Med Sci. 2012 Nov;4(11):582-5. PMID: 23181231.
Nguyen TV, Jayaraman A, Quaglino A, et al. Androgens selectively protect against apoptosis in hippocampal neurones. J Neuroendocrinol. 2010 Sep;22(9):1013-22. PMID: 20561156.