LKT Labs

Biochemicals for Life Science Research

Amlodipine Besylate

Amlodipine Besylate

Product ID A5044
Cas No. 111470-99-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $74.90 In stock
10 g $401.50 In stock
5 g $299.60 In stock
Bulk Quote

Quicklinks

Description

Amlodipine is a dihydropyridine L-type Ca2+ channel blocker that exhibits antihypertensive, anti-anginal, and vasodilatory activities. Amlodipine is clinically used to treat hypertension and angina as it induces relaxation of arterial smooth muscles, decreases blood pressure, and increases blood flow to the heart. Amlodipine also inhibits acid sphingomyelinase (FIASMA), which is involved in programmed cell death. Additionally, this compound improves smooth muscle hypertrophy and collagen deposition, preventing arterial remodeling in hypertensive rats.

Product Info

Cas No.

111470-99-6
Purity

≥98%
Formula

C20H25ClN2O5 • C6H5SO3H
Formula Wt.

567.06
Chemical Name

2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4- dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate
IUPAC Name

benzenesulfonic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1, 4-dihydropyridine-3,5-dicarboxylate
Synonym

Amlodipine Benzenesulfonate, Amlor, Istin, Monopina, Norvasc
Melting Point

195-204°C

Solubility

Slightly soluble in water. Sparingly soluble in ethanol. soluble in DMSO(113mg/ml)
Appearance

Almost White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

A5044 MSDS PDF
Info Sheet

A5044 Info Sheet PDF

References

Chen JL, Shang QH, Hu W, et al. Role of TGF-β1/Smads pathway in carotid artery remodeling in renovascular hypertensive rats and prevention by Enalapril and Amlodipine. J Geriatr Cardiol. 2012 Jun;9(2):185-91. PMID: 22916067.

Kornhuber J, Tripal P, Reichel M, et al. Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications. Cell Physiol Biochem. 2010;26(1):9-20. PMID: 20502000.

Wang JG. A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention. Vasc Health Risk Manag. 2009;5:593-605. PMID: 19688100.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D1644

    Deltorphin I

    Opioid peptide; δOR agonist.
    ≥98%
  • E7230

    Ethambutol Dihydrochloride

    Arabinosyl transferase inhibitor.
    ≥98%
  • R1877

    all-trans-Retinol, ≥98 %

    Diterpene vitamin A; RAR/RXR agonist.
    ≥98%
  • M1752

    Men 10376

    Peptide; NK2 antagonist.
    ≥95%
  • G0104

    Gabexate Mesylate

    Proteasome inhibitor.
    ≥98%
  • J0274

    Jasplakinolide

    Marine toxin; actin polymerization inducer.
    ≥98%
  • P0007

    Pituitary Adenylate Cyclase-activating Polypeptide (6-27), human, sheep, rat

    Endogenous peptide, involved in paracrine and auto...
    ≥95%
  • G6803

    Granuliberin R

    Antimicrobial peptide found in amphibians.
    ≥95%
  • C0366

    Carvedilol Phosphate Hemihydrate

    FIASMA; α1- and β1/2-adrenergic antagonist.
    ≥98%
  • T1855

    Tentoxin

    Cyclic peptide mycotoxin produced by Alternaria; C...
    ≥98%, HPLC
  • G3552

    20S-Ginsenoside Rg3

    Triterpene saponin found in Panax; Kv7.1 K+ channe...
    ≥98%
  • A9834

    Azithromycin Dihydrate

    Azalide macrolide; protein translation inhibitor.
    ≥98%
  • W0272

    S-(−)-Warfarin >99

    Coumarin, more potent isomer; VKORC1 inhibitor.
    ≥98%
  • D3203

    Diallyl Tetrasulfide

    Organosulfur found in garlic; Microtubule polymeri...
    ≥90%
  • P0010

    Pituitary Adenylate Cyclase-activating Polypeptide-related Peptide, human

    Peptide, involved in paracrine and autocrine cell ...
    ≥95%
  • T5968

    Torsemide

    Loop diuretic; NKCC symporter and HSP90 inhibitor.
    ≥98%
  • N0161

    β-Naphthoflavone

    AhR agonist.
    ≥98%
  • C1844

    Celastrol

    Triterpene isolated Trypterigium wilfordii; HSP90 ...
    ≥98%
  • G2968

    Growth Hormone Releasing Peptide 2

    Endogenous peptide hormone, involved in growth hor...
    ≥95%
  • L9600

    LY-2090314

    GSK-3 inhibitor.
    ≥98%