LKT Labs

Biochemicals for Life Science Research

Amlexanox

Amlexanox

Product ID A4944
Cas No. 68302-57-8
Purity ≥98%
Product Unit SizeCostQuantityStock
500 mg $64.70 In stock
1 g $92.30 In stock
5 g $369.40 In stock
Bulk Quote

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Description

Amlexanox is an azoxanthone derivative that is used to treat recurring aphthous ulcer and asthma. Amlexanox alters cytoskeleton function and inhibits cell migration and proliferation through binding to S100A12 and S100A13 proteins and attenuation of actin stress fiber formation and FGF1 release. Amlexanox may exhibit its anti-allergic activity through inhibition of 5- and 12-lipoxygenase, and also through inhibition of histamine release from mast cells. This compound also displays anti-obesity and anti-diabetic properties through its inhibition of TANK-binding kinase 1 (TBK1) and IκB kinase (IKK); this activity increases energy expenditure, thermogenesis, and weight loss, and also improves insulin sensitivity.

Product Info

Cas No.

68302-57-8
Purity

≥98%
Formula

C16H14N2O4
Formula Wt.

298.29
IUPAC Name

2-amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid
Solubility

Ethanol (0.58 mg/ml), DMSO (10 mg/ml), DMF (14 mg/ml), and 1:1 DMSO: PBS (pH 7.2) (0.5 mg/ml)
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

A4944 MSDS PDF
Info Sheet

A4944 Info Sheet PDF

References

Reilly SM, Chiang SH, Decker SJ, et al. An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar;19(3):313-21. PMID: 23396211.

Bell J. Amlexanox for the treatment of recurrent aphthous ulcers. Clin Drug Investig. 2005;25(9):555-66. PMID: 17532700.

Landriscina M, Prudovsky I, Mouta Carreira C, et al. Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in vitro. J Biol Chem. 2000 Oct 20;275(42):32753-62. PMID: 10921913.

Shishibori T, Oyama Y, Matsushita O, Yet al. Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. Biochem J. 1999 Mar 15;338 ( Pt 3):583-9. PMID: 10051426.

Makino H, Saijo T, Ashida Y, et al. Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase. Int Arch Allergy Appl Immunol. 1987;82(1):66-71. PMID: 2433225.

Saijo T, Makino H, Tamura S, et al. The antiallergic agent amoxanox suppresses SRS-A generation by inhibiting lipoxygenase. Int Arch Allergy Appl Immunol. 1986;79(3):231-7. PMID: 2868995.

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