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Amifostine is a thiol prodrug that exhibits antioxidative activity. Amifostine is co-administered with chemotherapeutics to detoxify their metabolites and scavenge for free radicals, protecting normal tissue and DNA against chemotherapy- or radiation-induced damage. TEST!!!!!!
| Cas No. | 112901-68-5 |
|---|---|
| Purity | ≥98% |
| Formula | C5H15N2O3PS • 3H2O |
| Formula Wt. | 268.27 |
| Chemical Name | Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester), trihydrate |
| IUPAC Name | 2-(3-aminopropylamino)ethylsulfanylphosphonic acid |
| Synonym | Ethiofos, Gammaphos, SAPEP, Ethyol |
| Melting Point | 160–161°C |
| Solubility | Soluble in water. |
| Appearance | White or almost white crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Chen C, Tian L, Zhang M, et al. Protective effect of amifostine on high-dose methotrexate-induced small intestinal mucositis in mice. Dig Dis Sci. 2013 Nov;58(11):3134-43. PMID: 23979434.
Lv W, Zhang M, Zhang Z, et al. Amifostine acts upon mitochondria to stimulate growth of bone marrow and regulate cytokines. Adv Exp Med Biol. 2013;789:195-201. PMID: 23852495.
Wozniak K, Gloc E, Morawiec Z, et al. Amifostine can differentially modulate DNA double-strand breaks and apoptosis induced by idarubicin in normal and cancer cells. Exp Oncol. 2008 Mar;30(1):22-8. PMID: 18438337.
Kouvaris JR, Kouloulias VE, Vlahos LJ. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47. PMID: 17602063.