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Alfacalcidol is a vitamin D analog that requires 25-hydroxylation to become the active hormonal form of vitamin D3. Alfacalcidol is clinically used to treat osteoporosis, hyperparathyroidism, and renal bone disease. As an anti-osteoporotic, alfacalcidol increases bone strength and formation and displays anti-catabolic and anabolic effects on bone in vivo.
| Cas No. | 41294-56-8 |
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| Purity | ≥98% |
| Formula | C27H44O2 |
| Formula Wt. | 400.64 |
| IUPAC Name | (1R,3S,5E)-5-[(2Z)-2-[(1R,3aS, 7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6, 7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1, 3-diol |
| Synonym | 1-Hydroxyvitamin D3, 1-Hydroxycholecalciferol (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol |
| Melting Point | 136°C |
| Solubility | Soluble in THF and methanol. |
| Appearance | White Crystalline Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Mazzaferro S, Goldsmith D, Larsson TE, et al. Vitamin D Metabolites and/or Analogs: Which D for Which Patient? Curr Vasc Pharmacol. 2014 Mar;12(2):339-49. PMID: 23713876.
Hara S, Kishimoto KN, Okuno H, et al. Effects of alfacalcidol on back extensor strength gained through back extensor exercise in postmenopausal women with osteoporosis. Am J Phys Med Rehabil. 2013 Feb;92(2):101-10. PMID: 23044701.
Chen H, Tian X, Liu X, et al. Alfacalcidol-stimulated focal bone formation on the cancellous surface and increased bone formation on the periosteal surface of the lumbar vertebrae of adult female rats. Calcif Tissue Int. 2008 Feb;82(2):127-36. PMID: 18175034.