Aeroplysinin

Name: Aeroplysinin
SKU: A1865
Availability: InStock

Product ID A1865

Cas No. 28656-91-9

Purity ≥90%

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Description

Aeroplysinin is a marine sponge alkaloid that exhibits antibiotic, anti-angiogenic, and anticancer activities. Aeroplysinin is used by Aplysia sponges as an antibacterial defense mechanism. In endothelial cells and monocytes, aeroplysinin decreases levels of MCP-1, TSP-1, MMP-1, COX-2, and IL-1α. Additionally, aeroplysinin inhibits capillary tube formation and cell growth and migration in vitro as well as angiogenesis in vivo. This compound also inhibits cell growth and causes cell death in Ehrlich ascites tumor cells. TEST!!!!!!

Product Info

Cas No.	28656-91-9
Purity	≥90%
Formula	C₉H₉Br₂NO₃
Formula Wt.	338.98
Chemical Name	3,5-dibromo-1,5-dihydroxy-4-methoxy-2,4-cyclo- hexadiene-1-acetonitrile
IUPAC Name	2-[(1S,6R)-3,5-dibromo-1,6-dihydroxy-4-methoxycyclohexa-2, 4-dien-1-yl]acetonitrile
Synonym	(1S-trans)-3,5-Dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1- acetonitrile
Solubility	Soluble in DMSO or ethanol.
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	A1865 MSDS PDF
Info Sheet	A1865 Info Sheet PDF

References

Martínez-Poveda B, García-Vilas JA, Cárdenas C, et al. The brominated compound aeroplysinin-1 inhibits proliferation and the expression of key pro- inflammatory molecules in human endothelial and monocyte cells. PLoS One. 2013;8(1):e55203. PMID: 23383109.

Rodríguez-Nieto S, González-Iriarte M, Carmona R, et al. Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge. FASEB J. 2002 Feb;16(2):261-3. PMID: 11772945.

Koulman A, Proksch P, Ebel R, et al. Cytotoxicity and mode of action of aeroplysinin-1 and a related dienonefrom the sponge Aplysina aerophoba. J Nat Prod. 1996 Jun;59(6):591-4. PMID: 8786366.

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Aeroplysinin

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