LKT Labs

Biochemicals for Life Science Research

Awaiting product image

Actinomycin

Product ID A0977
Cas No. 50-76-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $97.00 In stock
10 mg $176.40 In stock
Bulk Quote

Quicklinks

Description

Actinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA, preventing chain elongation and inhibiting RNA polymerase and topoisomerase activity. In cellular and animal models of chronic lymphocytic leukemia (CLL), this compound downregulates expression of Bcl-2 and Mcl-1, induces apoptosis, inhibits cellular proliferation, and decreases tumor burden.

Product Info

Cas No.

50-76-0
Purity

≥98%
Formula

C62H86N12O16
Formula Wt.

1255.50
IUPAC Name

2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12, 15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11, 14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
Synonym

Actinomycin D, Meractinomycin, Dactinomycin, TEST TEST TEST
Melting Point

245-255°C (dec.)
Solubility

Soluble in ethanol, propylene glycol, water + glycol mixture. Soluble in DMSO (50 mg/mL), methanol (10 mg/mL).
Appearance

Salmon Pink Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

A0977 MSDS PDF
Info Sheet

A0977 Info Sheet PDF

References

Merkel O, Wacht N, Sifft E, et al. Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. Leukemia. 2012 Dec;26(12):2508-16. PMID: 22743622.

Koba M, Konopa J. Actinomycin D and its mechanisms of action. Postepy Hig Med Dosw (Online). 2005;59:290-8. PMID: 15995596.

Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31. PMID: 2410919.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C4557

    Clofibrate

    Fibrate; PPARα agonist.

    ≥98%
  • G124082

    GDC-0941

    pan-PI3K inhibitor.

    ≥98%
  • C4534

    Clindamycin Palmitate Hydrochloride

    Lincosamide; ribosomal translocation and protei...

    ≥98%
  • G3461

    Ginsenoside F2

    Triterpene saponin found in species of Panax.

    ≥98%
  • L493400

    LMK-235

    Selective HDAC4 and HDAC5 inhibitor.

    ≥98%
  • P0278

    Patulin

    Mycotoxin produced by Penicillum and Aspergillu...

    ≥98%
  • A5313

    Andrographolide

    Labdane diterpene found in Andrographis; RLR (R...

    ≥98%
  • B8261

    Bupivacaine

    BK/SK, Kv1, Kv3, TASK-2 K+ channel blocker, vol...

    ≥98%
  • M0113

    Madecassoside

    Triterpenoid found in Centella.

    ≥90%
  • L0528

    LBH-589

    HDAC1/2/3/11 inhibitor.

    ≥98%
  • I8618

    Ivermectin

    Avermectin; glu-gated Cl- channel activator, Gl...

    ≥95%
  • M1575

    7-Methyl-6-mercaptopurine

    Thiopurine antimetabolite; PRPP amidotransferas...

    ≥87%
  • A2052

    Aflatoxin M1

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • F1655

    Fenoprofen Calcium Dihydrate

    NSAID; COX-1/2 inhibitor.

    ≥97%
  • D3201

    Diallyl Sulfide

    Organosulfur found in garlic.

    ≥97%
  • E6432

    (−)-Epinephrine

    Active isomer of epinephrine, endogenous hormon...

    ≥98%
  • H966144

    6-Hydroxydopamine Hydrobromide

    Neurotoxin frequently used to aid in modeling P...

    ≥98%
  • L920000

    LX-2343

    Promotes Aβ clearance.

    ≥98%
  • B5648

    Bombesin

    GRP analog, found in Bombina; bombesin and GRP ...

    ≥95%