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Aconitine is a toxin found in Aconitum that exhibits antipyretic, antihypertensive, analgesic, and antinociceptive activities. Aconitine binds neurotoxin binding site 2 of Na+ channels, forcing the channel to stay open longer, allowing continual depolarization, Na+ influx, and eventually paralysis. Aconitine acts as a positive inotrope, potentially inducing cardiac arrhythmia.
| Cas No. | 302-27-2 |
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| Purity | ≥95% |
| Formula | C34H47NO11 |
| Formula Wt. | 645.74 |
| Chemical Name | (1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy- 4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate |
| Synonym | 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diyl 8-acetate 14-benzoate: Acetylbenzoylaconine |
| Melting Point | 204°C |
| Solubility | Soluble in water (0.3 mg/mL) or ethanol (35 mg/mL). |
| Appearance | White Crystal |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Chan TY. Aconite poisoning. Clin Toxicol (Phila). 2009 Apr;47(4):279-85. PMID: 19514874.
Gutser UT, Friese J, Heubach JF, et al. Mode of antinociceptive and toxic action of alkaloids of Aconitum spec. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):39-48. PMID: 9459571.
Okazaki M, Kimura I, Kimura M. Aconitine-induced increase and decrease of acetylcholine release in the mouse phrenic nerve-hemidiaphragm muscle preparation. Jpn J Pharmacol. 1994 Dec;66(4):421-6. PMID: 7723217.