LKT Labs

Biochemicals for Life Science Research

Awaiting product image

Acalabrutinib

Product ID A081014
Cas No. 1420477-60-6
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $85.00 Please Inquire
25 mg $225.00 Please Inquire
100 mg $650.00 Please Inquire
Bulk Quote

Quicklinks

Description

Acalabrutinib is an inhibitor of Bruton’s tyrosine kinase (BTK). It showed increased selectivity compared with first generation BTK inhibitors such as ibrutinib while offering similar antitumor efficacy in mouse models of chronic lymphocytic leukemia. It has been approved for the treatment of patients with relapsed mantle cell lymphoma(MCL), a unique type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1. It is currently being investigated as a front line treatment for MCL. TEST!!!!!!

Product Info

Cas No.

1420477-60-6
Purity

≥99%
Formula

C26H23N7O2
Formula Wt.

465.52
IUPAC Name

4-{8-Amino-3-[(2S)-1-(2-butynoyl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl}-N-(2-pyridinyl)benzamide
Synonym

ACP-196

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A081014 MSDS PDF
Info Sheet

A081014 Info Sheet PDF

References

Herman S., Montraveta A., et al. The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia. Clin Cancer Res. 23(11):2831-41 (2016). PMID:27903679.

Witzig T., Inwards D. Acalabrutinib for mantle cell lymphoma. Blood. 133(24):2570-74 (2019). PMID: 30967367.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H1695

    S-Hexylglutathione

    Glutathione-S-transferase inhibitor.

    ≥98%
  • E2258

    Efonidipine Hydrochloride

    Calcium channel blocker.

    ≥98%
  • S800000

    SU-9516

    CDK2 inhibitor.

    ≥98%
  • G1869

    Geranylgeraniol

    Diterpene alcohol, geranylgeranyl pyrophosphate...

    ≥95%
  • B8072

    3-tert-Butyl-5-Methoxycatechol

    BHA derivative, cellular differentiation induce...

    ≥98%
  • M4455

    MLN-2238

    Proteasome inhibitor, miR33b modulator.

    ≥98%
  • B3272

    Bis(3,5-dibromosalicyl) Fumarate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥91%
  • B6856

    5-Bromo-2′-Deoxyuridine

    Nucleoside (thymidine) analog.

    ≥98%
  • S8047

    R,S-Sulforaphane, Research Grade

    Synthetic ITC.

    ≥97%
  • D170310

    10,11-Dehydrocurvularin

    ≥98%
  • C0269

    β-Carotene

    Red-orange terpene pigment found in various pla...

    ≥97%
  • F5668

    Forskolin

    Labdane diterpene found in Coleus; PP2A and ade...

    ≥98%
  • A5001

    Aminopterin

    Folic acid analog, derivative of pterin; dihydr...

    ≥95%
  • G1650

    Geniposide

    Iridoid glycoside found in Gardenia.

    ≥98%
  • L0400

    LB-100

    PP2A inhibitor.

    ≥98%
  • T0116

    2″,3″-Dihydrocephalomannine

    Cephalomannine derivative found in Taxus; poten...

    ≥90%
  • Q8133

    Quinacrine Dihydrochloride Dihydrate

    Cell membrane permeability modulator, topoisome...

    ≥97%
  • T2402

    TG100-115

    p110δ and p110γ PI3K inhibitor.

    ≥98%
  • B8070

    2-tert-Butyl-4-Hydroxyanisole

    BHA derivative, antioxidative food and cosmetic...

    ≥99%
  • C0170

    N-(4-Carbethoxyphenyl)retinamide

    Retinoid, differentiation inducer.

    ≥98%