7-Methyl-6-mercaptopurine

Name: 7-Methyl-6-mercaptopurine
SKU: M1575
Availability: InStock

Product ID M1575

Cas No. 3324-79-6

Purity ≥87%

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Description

7-Methyl-6-mercaptopurine is a thiopurine antimetabolite and derivative of 6-mercaptopurine; it exhibits immunosuppressive, anti-inflammatory, and anticancer chemotherapeutic activities. This compound is clinically used to treat inflammatory bowel disorder (IBD), Crohn’s disease, and leukemias and lymphomas. This compound suppresses metabolism of inosine monophosphate (IMP), inhibiting phosphoribosylpyrophosphate amidotransferase; this prevents synthesis of purines, DNA, and RNA. TEST!!!!!!

Product Info

Cas No.	3324-79-6
Purity	≥87%
Formula	C₆H₆N₄S
Formula Wt.	166.21
Chemical Name	1,7-dihydro-7-methyl-6H-Purine-6-thione
IUPAC Name	7-methyl-3H-purine-6-thione
Synonym	7-Methyl-6-thiopurine, 7-Methylpurine-6-thiol
Melting Point	286-288°C
Solubility	Soluble in DMSO.
Appearance	White Crystalline Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

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Info Sheet	M1575 Info Sheet PDF

References

Bradford K, Shih DQ. Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease. World J Gastroenterol. 2011 Oct 7;17(37):4166-73. PMID: 22072847.

Nielsen OH, Vainer B, Rask-Madsen J. Review article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine. Aliment Pharmacol Ther. 2001 Nov;15(11):1699-708. PMID: 11683683.

Lennard L, Welch JC, Lilleyman JS. Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity. Br J Clin Pharmacol. 1997 Nov;44(5):455-61. PMID: 9384462.

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7-Methyl-6-mercaptopurine

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Description

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