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5-Fluorocytosine, or Flucytosine, is a synthetic fluorinated pyrimidine analog that is used as an antifungal agent. In the presence of the enzyme cytosine deaminase it is converted to 5-fluorouracil, an antimetabolite that is an inhibitor of thymidylate synthase.
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| Cas No. | 2022-85-7 |
|---|---|
| Purity | ≥98% |
| Formula | C4H4FN3O |
| Formula Wt. | 129.09 |
| Chemical Name | 6-amino-5-fluoro-2(1H)-pyrimidinone |
| IUPAC Name | 4-Amino-5-fluoro-2(1H)-pyrimidinone |
| Synonym | Flucytosine, Ancobon, Ancotil, 5-FC, NSC 103805, Ro 2-9915 |
| Solubility | Soluble in water (1.5 g/100 mL or 0.089 M). |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Huang TT, Parab S, Burnett R, et al. Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model. Hum Gene Ther. 2015 Feb; 26(2):82-93. PMID: 25419577.
Davoudi N, Khamesipour A, Mahboudi F, McMaster WR. A dual drug sensitive L. major induces protection without lesion in C57BL/6 mice. PLoS Negl Trop Dis. 2014 May 29; 8(5):e2785. PMID: 24873970.
O’Connor L, Livermore J, Sharp AD, et al. Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients. J Infect Dis. 2013 Jul 15; 208(2):351-361. PMID: 23599314.