A recently published article in the Journal of Molecular Medicine examines the connection between the aryl hydrocarbon receptor and VEGF, a regulator of angiogenesis potentially involved in airway remodeling and other characteristics of pulmonary disease development. This study shows that synthetic aryl hydrocarbon receptor agonists increase VEGF expression, promoting tube formation in endothelial cells. Similarly, administration of environmental toxicants known to bind the aryl hydrocarbon receptor increased VEGF expression in bronchial epithelial cells of animal models.
These results indicate a role for the aryl hydrocarbon receptor in the development of airway remodeling, one physiological characteristic of asthma and other pulmonary diseases. Further research may provide a role for antagonism of the aryl hydrocarbon receptor in preventing the development of these diseases, particularly those related to environmental toxicants.
For more information on the original study, click here.
LKT carries several compounds that modulate aryl hydrocarbon receptor activity! Click the representative links below for more information.
- L1817 Leflunomide
- S7618 StemRegenin 1
- S8046 R-Sulforaphane