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EMD 1214063 is an inhibitor of c-MET that exhibits anticancer chemotherapeutic activity. In animal models of hepatocellular carcinoma, EMD 1214063 inhibits tumor growth and induces complete regression. In similar models of pancreatic cancer and glioblastoma, this compound also induces tumor regression.
| Cas No. | 1100598-32-0 |
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| Purity | ≥99% |
| Formula | C29H28N6O2 |
| Formula Wt. | 492.57 |
| Synonym | EMD1214063, MSC2156119J |
| Solubility | DMSO 5 mg/mL warmed (10.15 mM) Water Insoluble Ethanol Insoluble |
| Appearance | White to off white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Bladt F, Friese-Hamim M, Ihling C, et al. The c-Met Inhibitor MSC2156119J Effectively Inhibits Tumor Growth in Liver Cancer Models. Cancers (Basel). 2014 Aug 19;6(3):1736-52. PMID: 25256830.
Bladt F, Faden B, Friese-Hamim M, et al. EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors. Clin Cancer Res. 2013 Jun 1;19(11):2941-51. PMID: 23553846.