LKT Labs

Biochemicals for Life Science Research

GDC-0623

GDC-0623

Product ID G1210
Cas No. 1168091-68-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $131.00 In stock
5 mg $434.80 In stock
10 mg $695.50 In stock
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Description

GDC-0623 is an inhibitor of MEK that prevents MEK-dependent B-Raf and KRAS signaling. GDC-0623 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for several cancers.

Product Info

Cas No.

1168091-68-6
Purity

≥98%
Formula

C16H14FIN4O3
Formula Wt.

456.21
IUPAC Name

5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
Solubility

DMSO 91 mg/mL warmed (199.46 mM) Ethanol 5 mg/mL warmed (10.95 mM) Water Insoluble
Appearance

Beige Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

G1210 MSDS PDF
Info Sheet

G1210 Info Sheet PDF
Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Hatzivassiliou G, Haling JR, Chen H, et al. Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature. 2013 Sep 12;501(7466):232-6. PMID: 23934108.

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