LKT Labs

Biochemicals for Life Science Research

Dapoxetine Hydrochloride

Dapoxetine Hydrochloride

Product ID D0263
Cas No. 129938-20-1
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $52.50 In stock
50 mg $180.00 In stock
100 mg $299.60 In stock
Bulk Quote

Quicklinks

Description

Dapoxetine hydrochloride was initially designed as an antidepressant but was found more beneficial in the treatment of premature ejaculation due to its lack of significant effects on mood and quick adsorption and elimination kinetics. Dapoxetine is a centrally-acting SSRI that modulates serotonin levels in relevant areas such as the lateral paragigantocellular nucleus through inhibition of the serotonin transporter (SERT). This compound also decreases peak amplitude and accelerates the decay rate of current inactivation in a variety of voltage-gated K+ channels.

Product Info

Cas No.

129938-20-1
Purity

≥99%
Formula

C21H23NO • HCl
Formula Wt.

341.87
IUPAC Name

(1S)-N, N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine;hydrochloride
Melting Point

180-182°C
Solubility

Soluble in DMSO (68 mg/ml at 25° C), chloroform, methanol, water (68 mg/ml at 25° C), and ethanol (68 mg/ml at 25° C).
Appearance

Off-White powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

D0263 MSDS PDF
Info Sheet

D0263 Info Sheet PDF

References

McMahon CG. Dapoxetine: a new option in the medical management of premature ejaculation. Ther Adv Urol. 2012 Oct;4(5):233-51. PMID: 23024705.

Jeong I, Yoon SH, Hahn SJ. Effects of dapoxetine on cloned Kv1.5 channels expressed in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2012 Jul;385(7):707-16. PMID: 22568341.

Jeong I, Kim SW, Yoon SH, et al. Block of cloned Kv4.3 potassium channels by dapoxetine. Neuropharmacology. 2012 Jun;62(7):2261-6. PMID: 22192593.

Clément P, Bernabé J, Gengo P, et al. Supraspinal site of action for the inhibition of ejaculatory reflex by dapoxetine. Eur Urol. 2007 Mar;51(3):825-32. PMID: 17064843.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • O4917

    Omeprazole

    H+/K+ ATPase inhibitor.
    ≥98%
  • R3224

    Rigin

    Peptide, IgG derivative, tuftsin analog.
    ≥95%
  • L8011

    D-Luciferin Sodium

    Heterocyclic light-emitting compound, natural liga...
    ≥99%
  • B1977

    Betulin

    Pentacyclic triterpene found in various plant sour...
    ≥98%
  • G3454

    Ginsenoside Rb1

    Triterpene saponin found in species of Panax.
    ≥98%
  • V3251

    Vinorelbine Base

    Semi-synthetic vinca alkaloid found in Catharanthu...
    ≥90%
  • M0009

    Macitentan

    ET-A/B antagonist.
    ≥99%
  • P004094

    N-Cinnamoyl-N-debenzoyl Paclitaxel

    N-Cinnamoyl-N-debenzoyl Paclitaxel is a paclitaxel...
    ≥95%
  • D3230

    1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-hydroxy-3-phenyl-propan-1-one

    Minor kavalactone originally found in Piper methys...
    ≥98%
  • I2056

    Ifosfamide

    Nitrogen mustard, DNA alkylator.
    ≥98%
  • D0004

    Dabrafenib

    B-Raf and c-Raf inhibitor.
    ≥98%
  • A8644

    AVL-292

    BTK inhibitor.
    ≥98%
  • T7037

    Triptorelin Acetate

    Peptide, GnRH analog.
    ≥95%
  • S2957

    Shogaol

    Phenol found in Zingiber; PPARγ agonist, 5-HT3 an...
    ≥98%
  • A9803

    Azathioprine

    Purine nucleotide analog, mercaptiopurine prodrug;...
    ≥98%
  • N5669

    Nordihydroguaiaretic Acid

    Phenol found in the creosote bush; 5-lipoxygenase,...
    ≥97%
  • W2933

    WHI-P131

    JAK3 and EGFR inhibitor.
    ≥98%
  • Z3444

    Zileuton

    5-Lipoxygenase inhibitor.
    ≥98%
  • W0270

    (±)-Warfarin Sodium Clathrate

    Coumarin; VKORC1 inhibitor.
    ≥98%
  • G1749

    Gemfibrozil

    Fibrate; PPARα agonist, enoyl-CoA reductase inhib...
    ≥98%