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AZD-3463 is an inhibitor of anaplastic lymphoma kinase (ALK) and insulin-like growth factor 1 receptor (IGF-1R). This compound exhibits anticancer chemotherapeutic activity, inhibiting proliferation by altering downstream ERK/Akt/STAT3 signaling. AZD-3463 has induced regression or stasis in in vivo lung cancer tumor models and in several drug-resistant cell lines.
| Cas No. | 1356962-20-3 |
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| Purity | ≥99% |
| Formula | C24H25ClN6O |
| Formula Wt. | 448.95 |
| IUPAC Name | N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl) pyrimidin-2-amine |
| Synonym | AZD3463 |
| Solubility | In DMSO(24mg/ml), water with 1 eq. of acid, insoluble in ethanol |
| Appearance | Yellow powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Abstract: Yang B. Discovery of AZD3463 as a novel ALK/IGFR dual inhibitor and its ability in overcoming acquired resistance to crizotinib. Protein Kinases in Drug Discovery Conference. 2013.