LKT Labs

Biochemicals for Life Science Research

Diltiazem Hydrochloride

Diltiazem Hydrochloride

Product ID D3447
Cas No. 33286-22-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $57.00 In stock
10 g $419.50 In stock
5 g $224.70 In stock
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Description

Diltiazem is a benzothiazepine-type compound that acts as an inhibitor of L-type Ca2+ channels. Diltiazem exhibits anti-arrhythmic, anti-anginal, anti-inflammatory, and cardioprotective activities. In animal models, diltiazem inhibits expression of IL-1β and CCL-12 and prevents formation of aortic aneurysms. In animal models of ischemia/reperfusion, diltiazem prevents dephosphorylation of connexin43 gap junction proteins. This compound may also inhibit cyclic nucleotide-gated (CNG) channels, which play a role in motor neuron excitability.

Product Info

Cas No.

33286-22-5
Purity

≥98%
Formula

C22H26N2O4S • HCl
Formula Wt.

450.98
Chemical Name

[(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
IUPAC Name

[(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2, 3-dihydro-1,5-benzothiazepin-3-yl] acetate;hydrochloride
Melting Point

231°C
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

D3447 MSDS PDF
Info Sheet

D3447 Info Sheet PDF

References

Mieth A, Revermann M, Babelova A, et al. L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects. Hypertension. 2013 Dec;62(6):1098-104. PMID: 24082061.

Matsushita S, Kurihara H, Watanabe M, et al. Inhibition of connexin43 dephosphorylation is involved in protective effects of diltiazem on cardiac function during hypoxic injury. Histol Histopathol. 2011 Mar;26(3):315-22. PMID: 21210344.

Podda MV, D'Ascenzo M, Leone L, et al. Functional role of cyclic nucleotide-gated channels in rat medial vestibular nucleus neurons. J Physiol. 2008 Feb 1;586(3):803-15. PMID: 18048449.

Joyal M, Cremer K, Pieper J, et al. Effects of diltiazem during tachycardia-induced angina pectoris. Am J Cardiol. 1986 Jan 1;57(1):10-4. PMID: 3942050.

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