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Naltriben is an antagonist at δ2-opioid receptors (D2ORs). Naltriben induces anxiety in animal models undergoing light/dark tests and open field activity measurements; it also inhibits opioid-induced reinforcement in conditioned place preference assays. Additionally, naltriben inhibits antinociceptive activities regulated by δORs in the spinal cord.
| Cas No. | 103429-31-8 |
|---|---|
| Purity | ≥95% |
| Formula | C50H67N11O11S2 |
| Formula Wt. | 1062.27 |
| Synonym | NTB, CTOP |
| Solubility | Soluble in water (1 mg/mL). |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Sugiyama A, Nagase H, Oka JI, et al. DOR2-selective but not DOR1-selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127. Neuropharmacology. 2013 Dec 12;79C:314-320. PMID: 24333676.
Billa SK, Xia Y, Morón JA. Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse. Eur J Neurosci. 2010 Aug;32(4):625-31. PMID: 20626460.
Tseng LF, Collins KA, Portoghese PS. Spinal delta 2 but not delta 1 opioid receptors are involved in intracerebroventricular beta-endorphin-induced antinociception in the mouse. Life Sci. 1993;52(19):PL211-5. PMID: 8387138.