LKT Labs

Biochemicals for Life Science Research

Indolicidin

Indolicidin

Product ID I5215
Cas No. 140896-21-5
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $189.00 In stock
1 mg $321.40 In stock
2.5 mg $567.00 In stock
Bulk Quote

Quicklinks

Description

Indolicidin is an antimicrobial peptide (AMP) that interacts with and disrupts membranes. Indolicidin binds negatively charged lipid membranes and induces release of vesicle contents but does not form pores like other AMPs. Indolicidin exhibits antibacterial, hemolytic, and anti-inflammatory activities. This peptide displays antibiotic activity against both gram positive and gram negative bacteria, inhibiting growth of Acinetobacter, Staphyloccocus, and Nocardia, among others. Additionally, indolicidin inhibits production of NO and iNOS in LPS-stimulated macrophages and inhibits production of TNF-α in various other cell lines.

Product Info

Cas No.

140896-21-5
Purity

≥95%
Formula

C100H132N26O13
Formula Wt.

1906.33
Solubility

Soluble in water (1 mg/mL), DMSO.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

I5215 MSDS PDF
Info Sheet

I5215 Info Sheet PDF

References

Vila-Farres X, Garcia de la Maria C, López-Rojas R, et al. In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii. Clin Microbiol Infect. 2012 Apr;18(4):383-7. PMID: 21672084.

Végh AG, Nagy K, Bálint Z, et al. Effect of antimicrobial peptide-amide: indolicidin on biological membranes. J Biomed Biotechnol. 2011;2011:670589. PMID: 21765635.

Rieg S, Kaasch AJ, Wehrle J, et al. Susceptibility of clinical Staphylococcus aureus isolates to innate defense antimicrobial peptides. Microbes Infect. 2011 Aug;13(8-9):761-5. PMID: 21473929.

Rokitskaya TI, Kolodkin NI, Kotova EA, et al. Indolicidin action on membrane permeability: carrier mechanism versus pore formation. Biochim Biophys Acta. 2011 Jan;1808(1):91-7. PMID: 20851098.

Rieg S, Meier B, Fähnrich E, et al. Differential activity of innate defense antimicrobial peptides against Nocardia species. BMC Microbiol. 2010 Feb 23;10:61. PMID: 20178618.

Nan YH, Park KH, Park Y, et al. Investigating the effects of positive charge and hydrophobicity on the cell selectivity, mechanism of action and anti-inflammatory activity of a Trp-rich antimicrobial peptide indolicidin. FEMS Microbiol Lett. 2009 Mar;292(1):134-40. PMID: 19191872.

Bowdish DM, Davidson DJ, Scott MG, et al. Immunomodulatory activities of small host defense peptides. Antimicrob Agents Chemother. 2005 May;49(5):1727-32. PMID: 15855488.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C1601

    Carcinoembryonic Antigen (605-613) analog

    Carcinoembryonic antigen epitope analog.
    ≥95%
  • B1879

    Betamethasone Valerate

    Synthetic steroid hormone; glucocorticoid agonist.
    ≥98%
  • N8277

    Nutlin-3

    Imidzoline derivative; MDM2 inhibitor.
    ≥95%
  • H9716

    (E,Z)-4-Hydroxytamoxifen

    Selective estrogen receptor modulator.
    ≥97%
  • M4454

    MLN-4924

    Nedd8-activating enzyme inhibitor.
    ≥99%
  • D1859

    2-Deoxy-D-glucose

    Glucose metabolism inhibitor, N-linked glycosylati...
    ≥99%
  • T1979

    Tetrahydrocoptisine

    Alkaloid compound originally found in Corydalis; A...
    ≥98%
  • A9713

    AZD-3514

    Androgen receptor downregulator.
    ≥98%
  • P3462

    Piperacillin

    β-lactam; penicillin binding protein inhibitor.
    ≥95%
  • B3472

    4,4′-(1,1′-Biphenyl-4,4′-diyldioxy)dianiline

    Potential VEGFR2, Met, RET, Axl, Ron, PDGFR, FGFR1...
    ≥98%
  • E0813

    Ecdysterone

    Natural steroid hormone produced by arthropods; ec...
    ≥96%
  • A5276

    Angiotensin I, human

    Endogenous peptide, cleavage product of angiotensi...
    ≥98%
  • K1677

    Ketoprofen

    NSAID; COX-1/2 and lactate dehydrogenase inhibitor...
    ≥98%
  • I0902

    Icaritin

    Flavonoid found in Epimedium.
    ≥98%
  • K9600

    KY-02111

    Wnt signaling inhibitor.
    ≥98%
  • A4852

    β-Amyloid Peptide (1-40)

    Endogenous APP peptide cleavage product, primary c...
    ≥95%
  • T2668

    TGR5 Receptor Agonist

    TGR5 agonist.
    ≥99%
  • T1750

    Temocapril Hydrochloride

    ACE inhibitor.
    ≥98%
  • K0036

    Kahweol Linoleate

    Diterpene found in coffee beans.
    ≥98%
  • R1860

    Repaglinide

    Sulfonylurea; ATP-sensitive K+ channel blocker.
    ≥98%