LKT Labs

Biochemicals for Life Science Research

[Tyr8]-Bradykinin

[Tyr8]-Bradykinin

Product ID B6811
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $88.10 Please Inquire
10 mg $151.20 Please Inquire
50 mg $264.70 Please Inquire
Bulk Quote

Quicklinks

Description

Bradykinin is a peptide that exhibits natriuretic, antioxidative, vasodilatory, and pro-angiogenic activities. Bradykinin stimulates bradykinin receptors and increases PLC activity, decreasing ENaC open probability, inhibiting distal nephron Na+ transport, and inducing natriuresis. In vitro, bradykinin decreases H2O2-induced senescence, increases activity of superoxide dismutase (SOD), and suppresses DNA damage, ROS production, and NADPH oxidase activity. Additionally, bradykinin increases expression of VEGF and promotes tube formation in prostate cancer cells.

Product Info

Purity

≥95%
Formula

C50H73N15O12
Formula Wt.

1076.23
Solubility

Soluble in water, acid.

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

B6811 MSDS PDF
Info Sheet

B6811 Info Sheet PDF

References

Mamenko M, Zaika O, Pochynyuk O. Direct regulation of ENaC by bradykinin in the distal nephron. Implications for renal sodium handling. Curr Opin Nephrol Hypertens. 2014 Mar;23(2):122-9. PMID: 24378775.

Yu HS, Wang SW, Chang AC, et al. Bradykinin promotes vascular endothelial growth factor expression and increases angiogenesis in human prostate cancer cells. Biochem Pharmacol. 2014 Jan 15;87(2):243-53. PMID: 24225154.

Dong R, Xu X, Li G, et al. Bradykinin inhibits oxidative stress-induced cardiomyocytes senescence via regulating redox state. PLoS One. 2013 Oct 25;8(10):e77034. PMID: 24204728.

Feher A, Cassuto J, Szabo A, et al. Increased tissue angiotensin-converting enzyme activity impairs bradykinin-induced dilation of coronary arterioles in obesity. Circ J. 2013;77(7):1867-76. PMID: 23603844.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B3374

    Bisacodyl

    Diphenylmethane derivative, stimulates colonic mus...
    ≥98%
  • R2711

    Recombinant HCV-Core Antigens

    Recombinant HIV core protein antigen fragment.
    ≥95%
  • D0244

    Dalcetrapib

    Cholesterol ester transfer protein inhibitor.
    ≥98%
  • C0248

    Calcineurin Substrate

    Peptide used to measure in vitro calcineurin activ...
    ≥96%
  • A5072

    Amsacrine

    Acridine derivative, DNA intercalator; topoisomera...
    ≥98%
  • R0348

    Ramelteon

    Melatonin analog; MT1/2 agonist.
    ≥98%
  • R3577

    Ritonavir

    HIV protease inhibitor.
    ≥98%
  • M184770

    4-O-Methylhonokiol

    Found in Magnolia officinalis.
    ≥98%
  • T5871

    Torin 2

    Tricyclic benzonaphthyridinone; mTORC1/2 inhibitor...
    ≥98%
  • D0005

    Dabrafenib Mesylate

    B-Raf and c-Raf inhibitor.
    ≥98%
  • D3420

    4-(3,4-Difluorobenzo)curcumin

    Curcumin derivative.
    ≥95%
  • I0801

    IC261

    Casein kinase 1 inhibitor.
    ≥98%
  • S0048

    Salicin

    Alcoholic β-glucoside found in willow bark, salic...
    ≥98%
  • C9808

    CZC-54252

    LRRK2 inhibitor.
    ≥98%
  • V0145

    Valinomycin

    Peptide, neutral ionophore.
    ≥98%
  • M1579

    Methazolamide

    Carbonic anhydrase inhibitor.
    ≥98%
  • M0172

    Mastoparan

    Antimicrobial peptide found in Vespula lewisii, ma...
    ≥95%
  • H9712

    (E)-4-Hydroxytamoxifen

    SERM.
    ≥97%
  • H9816

    2-Hydroxyestradiol

    Estradiol metabolite.
    ≥98%
  • I5034

    Imiquimod

    Imidazoquinoline nucleoside analog; TLR-7/8 agonis...
    ≥99.5%