LKT Labs

Biochemicals for Life Science Research

Awaiting product image

LY-294002 Hydrochloride

Product ID L960002
Cas No. 934389-88-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $35.00 In stock
5 mg $75.00 In stock
25 mg $215.00 In stock
100 mg $600.00 In stock
Bulk Quote

Quicklinks

Description

Water soluble form of LY-294002 (L4796). LY-294002 is an inhibitor of PI3K that is used to sensitize cancer cells to other co-administered anticancer chemotherapeutics. In macrophages and monocytes, LY-294002 inhibits NF-κB activity and decreases levels of p50 NF-κB; it also inhibits LPS-induced expression of IL-10. LY-294002 prevents ruffled border formation in osteoclasts by altering the binding of acidic vacuoles with the intercellular membrane. Additionally, this compound inhibits DNA-dependent protein kinase (DPK) activity and prevents the formation of NO. TEST!!!!!!

Product Info

Cas No.

934389-88-5
Purity

≥98%
Formula

C19H17NO3 • HCl
Formula Wt.

343.81
IUPAC Name

2-(4-Morpholinyl)-8-phenyl-4H-chromen-4-one hydrochloride (1:1)
Synonym

LY294002 HCl

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

L960002 MSDS PDF
Info Sheet

L960002 Info Sheet PDF

References

Avni D, Glucksam Y, Zor T. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor κB inhibition, in a PI3K-independent mechanism. Biochem Pharmacol. 2012 Jan 1;83(1):106-14. PMID: 22005520.

Salh B, Wagey R, Marotta A, et al. Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production. J Immunol. 1998 Dec 15;161(12):6947-54. PMID: 9862729.

Nakamura I, Sasaki T, Tanaka S, et al. Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts. J Cell Physiol. 1997 Aug;172(2):230-9. PMID: 9258344.

Rosenzweig KE, Youmell MB, Palayoor ST, et al. Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin Cancer Res. 1997 Jul;3(7):1149-56. PMID: 9815794.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B1752

    Benidipine Hydrochloride

    Calcium channel blocker.

    ≥98%
  • H9615

    17α-Hydroxyprogesterone Caproate

    Synthetic steroid hormone; ER antagonist.

    ≥98%
  • B6918

    Brevetoxin 3

    Polyether neurotoxin found in Karenia brevis; N...

    ≥95%
  • B4976

    BMS-794833

    MET, VEGFR2, Ron, Axl, FLT3 inhibitor.

    ≥98%
  • S9755

    (R)-Synephrine

    ≥98%
  • A5037

    Amiodarone Hydrochloride

    Voltage-gated Na+, Ca2+, K+ channel blocker, α...

    ≥98%
  • R5772

    Rosiglitazone Maleate

    Thiazolidinedione; PPARγ agonist.

    ≥98%
  • L920000

    LX-2343

    Promotes Aβ clearance.

    ≥98%
  • O4402

    Olaparib

    PARP1/2 inhibitor.

    ≥98%
  • L0360

    Lapatinib Ditosylate Monohydrate

    EGFR inhibitor.

    ≥98%
  • C0253

    Candesartan

    AT1 inhibitor.

    ≥98%
  • A5033

    4-Aminosalicylic Acid

    Dihydrofolate reductase inhibitor.

    ≥98%
  • C4656

    Clopidol

    Coccidiostat.

    ≥98%
  • H1695

    S-Hexylglutathione

    Glutathione-S-transferase inhibitor.

    ≥98%
  • U7354

    Usnic Acid

    Dibenzofuran produced by lichens.

    ≥98%
  • P9870

    Pyridostatin Hydrochloride

    G-quadruplex ligand; DNA breakage inducer.

    ≥98%
  • S8247

    Sulfasalazine

    Mesalazine derivative, sulfa drug; sepiapterin ...

    ≥98%
  • G337543

    Ginsenoside CK

    ≥98%
  • A5478

    Antipain Dihydrochloride

    Oligopeptide found in Actinomycetes; protease i...
  • T5769

    Toremifene Base

    SERM, androgen modulator.

    ≥98%