| Product Unit Size | Cost | Quantity | Stock |
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B02 is a RAD51 inhibitor. RAD51 is a homologous recombination protein, involved in the repair of double strand breaks in DNA. It is often overexpressed in cancers, making it an interesting target for anti-cancer therapies. Suppressing RAD51 activity increases the sensitivity of cancer cells to other therapies. In human breast cancer cells, B02 increased the anti-cancer effect of doxorubicin, etoposide, topotecan, and cisplatin. TEST!!!!!!
| Cas No. | 1290541-46-6 |
|---|---|
| Purity | ≥98% |
| Formula | C22H17N3O |
| Formula Wt. | 339.40 |
| IUPAC Name | 3-Benzyl-2-[(E)-2-(3-pyridinyl)vinyl]-4(3H)-quinazolinone |
| Synonym | B02 RAD51 inhibitor; |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Huang F., Mazin A., et al. A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts. PLoS One. 9(6): e100993 (2014). PMID: 24971740.