2’,3’-cGAMP Sodium Salt

Name: 2’,3’-cGAMP Sodium Salt
SKU: G016499
Availability: InStock

Product ID G016499

Cas No.

Purity ≥99%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

2’,3’-cGAMP sodium salt is a mammalian, noncanonical cyclic dinucleotide with a higher binding potency for human STING than 2’2’-cGAMP and 3’3’-cGAMP. The enzyme cGAMP synthase initiates cGAMP production in the presence of cytosolic DNA, triggering an immune response through the STING pathway. Addition of 2’,3’-cGAMP to vaccination of porcine reproductive and respiratory syndrome virus virus-like particles in piglets resulted in enhanced virus replication but did not increase disease severity.

Product Info

Purity	≥99%
Formula	C₂₀H₂₂N₁₀O₁₃P₂ • 2Na
Formula Wt.	718.38
IUPAC Name	disodium;2-amino-9-[(1R,6R,8R,9R,10S,15R,17R,18R)-8-(6-aminopurin-9-yl)-9,18-dihydroxy-3,12-dioxido-3,12-dioxo-2,4,7,11,13,16-hexaoxa-3λ5,12λ5-diphosphatricyclo[13.2.1.06,10]octadecan-17-yl]-1H-purin-6-one
Synonym	2’,3’-Cyclic GMP-AMP Sodium Salt; AKOS032949718; 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	G016499 MSDS PDF
Info Sheet	G016499 Info Sheet PDF

References

Wu, J., Sun, L., et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 339(6121), 826-830 (2013). PMID: 23258412.

Zhang, X., Shi, H., et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 51(2), 226-235 (2013). PMID: 23747010.

Van Noort A, Nelsen A, Pillatzki AE, et al. Intranasal immunization of pigs with porcine reproductive and respiratory syndrome virus-like particles plus 2’,3’-cGAMP VacciGrade adjuvant exacerbates viremia after virus challenge. Virol J. 2017 Apr 12;14(1):76. PMID: 28403874.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Comments
This field is for validation purposes and should be left unchanged.

2’,3’-cGAMP Sodium Salt

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Dalcetrapib

Peiminine

α-Calcitonin Gene Related Peptide, human

1,4-Benzoquinone

Anacetrapib

[D-Trp11]-Neurotensin

PF-03758309 Dihydrochloride

Ticagrelor

AZD-3463

Theaflavin-3-gallate

Tobramycin, Free Base

CM346 Hydrochloride

Oxolinic Acid

Florfenicol

SNA 1

Entecavir

7-(Triethylsilyl)-10-deacetylbaccatin III

Corticosterone

Cafestol Eicosanate

10-Deacetyltaxol

Footer