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Timolol is a non-selective β-adrenergic receptor antagonist that exhibits antihypertensive activity. Timolol is clinically used to induce vascular relaxation in the ciliary artery. Timolol decreases intraocular pressure in the treatment of glaucoma. TEST!!!!!!
| Cas No. | 26921-17-5 |
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| Purity | ≥98% |
| Formula | C13H24N4O3S • C4H4O4 |
| Formula Wt. | 432.50 |
| Chemical Name | (2S)-1-[(1,1-Dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol maleate |
| IUPAC Name | (Z)-but-2-enedioic acid;(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2, 5-thiadiazol-3-yl)oxy]propan-2-ol |
| Synonym | Betime, Blocadren, Istalol, Timacar, Timoptol: Proflax |
| Melting Point | 202-203°C |
| Solubility | Soluble in water, methanol, and ethanol. |
| Appearance | White powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Johnson TV, Fan S, Zhan G, et al. Efficacy and mechanisms of intraocular pressure reduction with latanoprost and timolol in participants with ocular hypertension: a comparison of 1 and 6 weeks of treatment. J Glaucoma. 2010 Aug;19(6):356-64. PMID: 20179619.
Dong Y, Ishikawa H, Wu Y, et al. Effect and mechanism of betaxolol and timolol on vascular relaxation in isolated rabbit ciliary artery. Jpn J Ophthalmol. 2006 Nov-Dec;50(6):504-8. PMID: 17180523.