LKT Labs

Biochemicals for Life Science Research

Irsogladine Maleate

Irsogladine Maleate

Product ID I7074
Cas No. 84504-69-8
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $102.00 In stock
500 mg $318.40 In stock
1 g $509.50 In stock
Bulk Quote

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Description

Irsogladine exhibits anti-inflammatory, anti-fibrotic, and mucoprotective activities. Irsogladine decreases non-steroidal anti-inflammatory drug (NSAID)-induced intestinal mucosal injury, ulcers, and esophagitis; it inhibits COX-1 and COX-2. In animal models of colitis, irsogladine prevents DDS-induced increases in TGF-β1, collagen type 1, MMP2, TIMP-1, and α-SMA, preventing fibrosis. Additionally, irsogladine non-selectively inhibits phosphodiesterases, increasing cAMP and NO, facilitating gap junction communication and altering gastric mucosal blood flow.

Product Info

Cas No.

84504-69-8
Purity

≥98%
Formula

C9H7Cl2N5 • C4H4O4
Formula Wt.

372.17
Chemical Name

6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate
IUPAC Name

(Z)-but-2-enedioic acid;6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine
Synonym

MN-1695, Gaslon

Melting Point

289-294°C
Solubility

Soluble in DMSO.

Appearance

White Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

I7074 MSDS PDF
Info Sheet

I7074 Info Sheet PDF

References

Kuramoto T, Umegaki E, Nouda S, et al. Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflammatory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study. BMC Gastroenterol. 2013 May 14;13:85. PMID: 23672202.

Akagi M, Amagase K, Murakami T, et al. Irsogladine: overview of the mechanisms of mucosal protective and healing- promoting actions in the gastrointestinal tract. Curr Pharm Des. 2013;19(1):106-14. PMID: 22950502.

Yamaguchi H, Suzuki K, Nagata M, et al. Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium. Med Mol Morphol. 2012 Jun;45(3):140-51. PMID: 23001296.

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