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Doxazosin is a quinazoline α1-adrenergic receptor inhibitor that exhibits antihypertensive and vasodilatory activities. Doxazosin is clinically used to treat hypertension and benign prostatic hyperplasia. Doxazosin induces Fas-mediated apoptosis in benign and malignant prostate cells. TEST!!!!!!
| Cas No. | 77883-43-3 |
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| Purity | ≥98% |
| Formula | C23H25N5O5 • CH3SO3H |
| Formula Wt. | 547.59 |
| Chemical Name | 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3- dihydro-1,4-benzodioxan-2-yl)carbonyl)piperazine methanesulfonate |
| IUPAC Name | [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1, 4-benzodioxin-3-yl)methanone;methanesulfonic acid |
| Synonym | Doxazosin Methanesulfonate, Alfadil, Benur, Cardular, Carduran, Normothen, Supressin, Zoxan |
| Melting Point | 275-277°C |
| Solubility | Slightly soluble in water. |
| Appearance | White or off-white Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Shannon R, Chaudhry M. Effect of alpha1-adrenergic receptors in cardiac pathophysiology. Am Heart J. 2006 Nov;152(5):842-50. PMID: 17070143.
Garrison JB, Kyprianou N. Doxazosin induces apoptosis of benign and malignant prostate cells via a death receptor-mediated pathway. Cancer Res. 2006 Jan 1;66(1):464-72. PMID: 16397262.
Kyprianou N. Doxazosin and terazosin suppress prostate growth by inducing apoptosis: clinical significance. J Urol. 2003 Apr;169(4):1520-5. PMID: 12629407.