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Aminophylline is a non-selective adenosine receptor antagonist and phosphodiesterase (PDE) inhibitor. Aminophylline exhibits vasodilatory and anti-inflammatory activity and is occasionally clinically used to treat chronic obstructive pulmonary disorder (COPD). In animal models of allergen-induced lung inflammation, aminophylline decreases levels of IL-5, IL-8, and eosinophils.
| Cas No. | 317-34-0 |
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| Purity | ≥98% |
| Formula | C16H24N10O4 |
| Formula Wt. | 420.43 |
| Chemical Name | 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione compd with 1,2-ethanediamine (2:1) |
| IUPAC Name | 1,3-dimethyl-7H-purine-2,6-dione;ethane-1,2-diamine |
| Synonym | Aminophylline, Afonilum, Cardophylin, Pecram, Phyllotemp, Tefamin |
| Melting Point | 269-270°C |
| Solubility | Soluble in water. Insoluble in alcohol and ether. |
| Appearance | A white or slightly yellowish powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Nickels TJ, Schwartz AD, Blevins DE, et al. Effect of theophylline and aminophylline on transmitter release at the mammalian neuromuscular junction is not mediated by cAMP. Clin Exp Pharmacol Physiol. 2006 May-Jun;33(5-6):465-70. PMID: 16700879.
Danahay H, Broadley KJ, McCabe PJ, et al. The potential roles of cytokines, IL-5 and IL-8, and plasma cortisol in the anti-inflammatory actions of phosphodiesterase inhibitors in sensitized guinea-pig airways. Pulm Pharmacol Ther. 1997 Oct-Dec;10(5-6):277-85. PMID: 9778491.