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Procarbazine is a hydrazine derivative that exhibits anticancer chemotherapeutic activity. Procarbazine acts as a DNA alkylator and induces double stranded DNA breaks and causes oxidative damage. Clinically, procarbazine is used to treat Hodgkin’s lymphoma and brain cancers. This compound also inhibits monoamine oxidase (MAO). TEST!!!!!!
| Cas No. | 366-70-1 |
|---|---|
| Purity | ≥97% |
| Formula | C12H19N3O • HCl |
| Formula Wt. | 257.76 |
| Chemical Name | N-(1-Methylethyl)-4-[(2- methylhydrazino)methyl]- benzamide hydrochloride |
| IUPAC Name | 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide;hydrochloride |
| Synonym | Matulane, Natulan |
| Melting Point | 223-226°C |
| Solubility | Soluble in water. |
| Appearance | White crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ogawa K, Hiraku Y, Oikawa S, et al. Molecular mechanisms of DNA damage induced by procarbazine in the presence of Cu(II). Mutat Res. 2003 Aug 5;539(1-2):145-55. PMID: 12948823.
Kyrtopoulos SA, Anderson LM, Chhabra SK, et al. DNA adducts and the mechanism of carcinogenesis and cytotoxicity of methylating agents of environmental and clinical significance. Cancer Detect Prev. 1997;21(5):391-405. PMID: 9307842.