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Ranitidine is an inverse agonist at H2 histamine receptors, inducing receptor desensitization and inhibiting downstream signaling. Ranitidine displays antacid activity and is clinically used to treat peptic ulcer disease and gastroesophageal reflux disease (GERD).
| Cas No. | 66357-59-3 |
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| Purity | ≥98% |
| Formula | C13H22N4O3S • HCl |
| Formula Wt. | 350.86 |
| Chemical Name | N-[2-[[[-5-[(Dimethylamino)methyl]-2-furanyl]- methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine |
| IUPAC Name | (E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]- 1-N-methyl-2-nitroethene-1,1-diamine;hydrochloride |
| Synonym | Azantac, Melfax, Noctone, Ranidil, Taural, Trigger, Ulcex, Zantac, Zantic |
| Melting Point | 133-134°C |
| Solubility | Soluble in acetic acid, water and methanol. Slightly soluble in ethanol. Practically insoluble in chloroform. |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Alonso N, Monczor F, Echeverría E, et al. Signal transduction mechanism of biased ligands at histamine H2 receptors. Biochem J. 2014 Apr 1;459(1):117-26. PMID: 24417223.
Rodriguez-Stanley S, Ciociola AA, Zubaidi S, et al. A single dose of ranitidine 150 mg modulates oesophageal acid sensitivity in patients with functional heartburn. Aliment Pharmacol Ther. 2004 Nov 1;20(9):975-82. PMID: 15521845.