LKT Labs

Biochemicals for Life Science Research

(−)-Epicatechin Gallate

(−)-Epicatechin Gallate

Product ID E6232
Cas No. 1257-08-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $38.30 In stock
5 mg $127.30 In stock
25 mg $374.60 In stock
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Description

(-)-Epicatechin gallate (ECG) is a flavanol/catechin originally found in Camilla and other plan sources; it exhibits antioxidative, neuromodulatory, anticancer, and anti-inflammatory activities. ECG displays agonist activity at cannabinoid 1 (CB1) receptors. ECG also inhibits expression of FLT3 and decreases phosphorylation of p38 MAPK, Akt, and STAT5 in acute myelogenous leukemia (AML) cells, suppressing cell proliferation. In vitro, this compound inhibits LPS- or peptidoglycan-induced production of VEGF and expression of COX-2.

Product Info

Cas No.

1257-08-5
Purity

≥98%
Formula

C22H18O10
Formula Wt.

442.37
Chemical Name

3,4,5-Trihydroxybenzoic acid, (2R,3R)-3,4- dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2-H-1-benzopyran-3-yl ester
IUPAC Name

[(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
Synonym

ECG
Melting Point

218°C

Solubility

Soluble in water or alcohol.
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

E6232 MSDS PDF
Info Sheet

E6232 Info Sheet PDF
Brochures

Green Tea Flyer

Brochures

Natural Products Booklet

References

Nakanishi T, Mukai K, Hosokawa Y, et al. Catechins inhibit vascular endothelial growth factor production and cyclooxygenase-2 expression in human dental pulp cells. Int Endod J. 2014 May 21. [Epub ahead of print]. PMID: 24847951.

Ly BT, Chi HT, Yamagishi M, et al. Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells. PLoS One. 2013 Jun 20;8(6):e66378. PMID: 23840454.

Korte G, Dreiseitel A, Schreier P, et al. Tea catechins' affinity for human cannabinoid receptors. Phytomedicine. 2010 Jan;17(1):19-22. PMID: 19897346.

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